Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China.
Identifieur interne : 005236 ( Main/Exploration ); précédent : 005235; suivant : 005237Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China.
Auteurs :Source :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2004.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Adaptation physiologique, Analyse de regroupements, Animaux, Cadres ouverts de lecture, Carnivora (virologie), Chine (épidémiologie), Conformation d'acide nucléique, Coronavirus (génétique), Coronavirus (isolement et purification), Données de séquences moléculaires, Délétion de séquence, Flambées de maladies, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Génome viral, Génotype, Humains, Mutation, Mutation ponctuelle, Phylogénie, Protéines de l'enveloppe virale (génétique), Protéines de la matrice virale (), Protéines de la matrice virale (génétique), Substitution d'acide aminé, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Sélection génétique, Séquence nucléotidique, Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Virus du SRAS (physiologie), Évolution moléculaire.
- MESH :
- génétique : ARN viral, Coronavirus, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Protéines de la matrice virale, Virus du SRAS.
- isolement et purification : Coronavirus, Virus du SRAS.
- physiologie : Virus du SRAS.
- virologie : Carnivora, Syndrome respiratoire aigu sévère.
- épidémiologie : Chine, Syndrome respiratoire aigu sévère.
- Adaptation physiologique, Analyse de regroupements, Animaux, Cadres ouverts de lecture, Conformation d'acide nucléique, Données de séquences moléculaires, Délétion de séquence, Flambées de maladies, Glycoprotéine de spicule des coronavirus, Génome viral, Génotype, Humains, Mutation, Mutation ponctuelle, Phylogénie, Protéines de la matrice virale, Substitution d'acide aminé, Sélection génétique, Séquence nucléotidique, Évolution moléculaire.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adaptation, Physiological, Amino Acid Substitution, Animals, Base Sequence, Carnivora (virology), China (epidemiology), Cluster Analysis, Coronavirus (genetics), Coronavirus (isolation & purification), Disease Outbreaks, Evolution, Molecular, Genome, Viral, Genotype, Humans, Membrane Glycoproteins (genetics), Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Open Reading Frames, Phylogeny, Point Mutation, RNA, Viral (genetics), SARS Virus (genetics), SARS Virus (isolation & purification), SARS Virus (physiology), Selection, Genetic, Sequence Deletion, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (genetics), Viral Matrix Proteins (chemistry), Viral Matrix Proteins (genetics).
- MESH :
- chemical , chemistry : Viral Matrix Proteins.
- chemical , genetics : Membrane Glycoproteins, RNA, Viral, Viral Envelope Proteins, Viral Matrix Proteins.
- geographic , epidemiology : China.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus, SARS Virus.
- isolation & purification : Coronavirus, SARS Virus.
- physiology : SARS Virus.
- virology : Carnivora, Severe Acute Respiratory Syndrome.
- Adaptation, Physiological, Amino Acid Substitution, Animals, Base Sequence, Cluster Analysis, Disease Outbreaks, Evolution, Molecular, Genome, Viral, Genotype, Humans, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Open Reading Frames, Phylogeny, Point Mutation, Selection, Genetic, Sequence Deletion, Spike Glycoprotein, Coronavirus.
Abstract
Sixty-one SARS coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome (SARS) epidemic were analyzed together with two viral sequences from palm civets. Genotypes characteristic of each phase were discovered, and the earliest genotypes were similar to the animal SARS-like coronaviruses. Major deletions were observed in the Orf8 region of the genome, both at the start and the end of the epidemic. The neutral mutation rate of the viral genome was constant but the amino acid substitution rate of the coding sequences slowed during the course of the epidemic. The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization.
DOI: 10.1126/science.1092002
PubMed: 14752165
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002F70
- to stream PubMed, to step Curation: 002F70
- to stream PubMed, to step Checkpoint: 002B89
- to stream Ncbi, to step Merge: 000588
- to stream Ncbi, to step Curation: 000588
- to stream Ncbi, to step Checkpoint: 000588
- to stream Main, to step Merge: 005632
- to stream Main, to step Curation: 005236
Le document en format XML
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<term>Base Sequence</term>
<term>Carnivora (virology)</term>
<term>China (epidemiology)</term>
<term>Cluster Analysis</term>
<term>Coronavirus (genetics)</term>
<term>Coronavirus (isolation & purification)</term>
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<term>Cadres ouverts de lecture</term>
<term>Carnivora (virologie)</term>
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<term>Conformation d'acide nucléique</term>
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<term>Coronavirus (isolement et purification)</term>
<term>Données de séquences moléculaires</term>
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<term>Flambées de maladies</term>
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<term>Glycoprotéines membranaires (génétique)</term>
<term>Génome viral</term>
<term>Génotype</term>
<term>Humains</term>
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<term>Mutation ponctuelle</term>
<term>Phylogénie</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de la matrice virale ()</term>
<term>Protéines de la matrice virale (génétique)</term>
<term>Substitution d'acide aminé</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Syndrome respiratoire aigu sévère (épidémiologie)</term>
<term>Sélection génétique</term>
<term>Séquence nucléotidique</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (isolement et purification)</term>
<term>Virus du SRAS (physiologie)</term>
<term>Évolution moléculaire</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Viral Matrix Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>RNA, Viral</term>
<term>Viral Envelope Proteins</term>
<term>Viral Matrix Proteins</term>
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<term>Protéines de l'enveloppe virale</term>
<term>Protéines de la matrice virale</term>
<term>Virus du SRAS</term>
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<term>SARS Virus</term>
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<term>Virus du SRAS</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Carnivora</term>
<term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term>
<term>Syndrome respiratoire aigu sévère</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adaptation, Physiological</term>
<term>Amino Acid Substitution</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cluster Analysis</term>
<term>Disease Outbreaks</term>
<term>Evolution, Molecular</term>
<term>Genome, Viral</term>
<term>Genotype</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Mutation</term>
<term>Nucleic Acid Conformation</term>
<term>Open Reading Frames</term>
<term>Phylogeny</term>
<term>Point Mutation</term>
<term>Selection, Genetic</term>
<term>Sequence Deletion</term>
<term>Spike Glycoprotein, Coronavirus</term>
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<term>Analyse de regroupements</term>
<term>Animaux</term>
<term>Cadres ouverts de lecture</term>
<term>Conformation d'acide nucléique</term>
<term>Données de séquences moléculaires</term>
<term>Délétion de séquence</term>
<term>Flambées de maladies</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Génome viral</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mutation</term>
<term>Mutation ponctuelle</term>
<term>Phylogénie</term>
<term>Protéines de la matrice virale</term>
<term>Substitution d'acide aminé</term>
<term>Sélection génétique</term>
<term>Séquence nucléotidique</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
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<front><div type="abstract" xml:lang="en">Sixty-one SARS coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome (SARS) epidemic were analyzed together with two viral sequences from palm civets. Genotypes characteristic of each phase were discovered, and the earliest genotypes were similar to the animal SARS-like coronaviruses. Major deletions were observed in the Orf8 region of the genome, both at the start and the end of the epidemic. The neutral mutation rate of the viral genome was constant but the amino acid substitution rate of the coding sequences slowed during the course of the epidemic. The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization.</div>
</front>
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